Convergent chemical synthesis of histone H2B protein for the site-specific ubiquitination at Lys34.
نویسندگان
چکیده
منابع مشابه
Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79.
Dot1 is a non-SET domain protein that methylates histone H3 at lysine 79, a surface-exposed residue that lies within the globular domain. In the context of a nucleosome, H3 lysine 79 is located in close proximity with lysine 123 of histone H2B, a major site for ubiquitination by Rad6. Here we show that Rad6-mediated ubiquitination of H2B lysine 123 is important for efficient methylation of lysi...
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ورودعنوان ژورنال:
- Angewandte Chemie
دوره 52 31 شماره
صفحات -
تاریخ انتشار 2013